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Using chemoproteomics, we identified a cysteine-reactive small molecule degrader of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) nonstructural protein 14 (nsp14), which effects degradation through direct modification of cysteines in both nsp14 and in host protein disulfide isomerases

Front Pharmacol (2024) 15:1374722

Proc Natl Acad Sci U S A[Internet]

It addresses functional B-vitamin insufficiency, particularly during periods of stress or increased metabolic demand, while avoiding imbalance that can occur when single B vitamins are given in isolation

8-OHdG Context: Reflects total body oxidative stress, not estrogen-specific, but reinforces metabolic-genotoxic overlap when paired with estrogen metabolite imbalances.