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Note that while elevated homocysteine is associated with an increased risk of Alzheimer's disease, systematic reviews of clinical trials comparing vitamin B12 supplementation to placebo groups have not shown a significant effect in preventing or slowing Alzheimer's disease or cognitive decline

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Estimates vary widely - from about 2.6% of the global population (roughly 200 million people) to as high as 26% (over 2 billion) - depending on how deficiency is defined and measured