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doi: 10.1016/S0140-6736(23)01429-0 71

The ratio of the fluorescence emission intensity upon excitation at 405 nm and 488 nm reflects changes in the dithiol disulfide state of the probe and, in combination with fully oxidized and reduced controls, allows the determination of the degree of the probe oxidation independent of probe concentration (Degrossoli et al., 2018

This aligns with the body-first PD subtype theory, suggesting that peripheral initiation may precede CNS involvement (Goedert et al., 2017

METHODS: We conducted a MEDLINE search (to 30 September 2015) of GSH use for skin lightening and of all indications in medicine, to evaluate its safety