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How does metformin (biguanide oral hypoglycemic agent) cause vitamin B12 deficiency?

doi: 10.1016/S0140-6736(23)00966-2 68

The deletion of ZIP14 resulted in a reduction in the expression of tight junction proteins occludin and claudin-1, accompanied by an increase in the expression of claudin-2, leading to decreased gut permeability (61, 139)

Growth Horm IGF Res 15 : 1927 Fryburg DA and Barrett EJ (1999) Physiological effects and potential applications of GH and IGF-I

AHK-Cu's primary human-relevant data the Pyo 2007 study (PMID 17703734) used human hair follicles and dermal papilla cells obtained for laboratory culture, not living research participants in a treatment trial