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The SURMOUNT-1 trial showed that FDA-approved tirzepatide produced average weight loss of 15% at 5mg, 19.5% at 10mg, and 20.9% at 15mg over 72 weeks

Adverse events were mild to moderate in severity, most commonly gastrointestinal disturbance (207 adverse events, 37%), with similar rates across treatment groups

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Liver pain is often described as a vague discomfort in the upper right quadrant of the abdomen

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