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Randomized controlled trials have demonstrated 60 to 100% reductions in NTD cases when women consumed folic acid supplements in addition to a varied diet during the month before and the month after conception

With regard to the amelioration of hyperglycemia in fat-transplanted Insr P1195L/ +/HFD mice, it is unclear whether the improved glucose uptake into the transplant may play a major role, as WAT has been reported to play a minor role in glucose uptake in rodents 20

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