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Similar content being viewed by others Log in or create a free account to read this content Gain free access to this article, as well as selected content from this journal and more on nature.com or Abbreviations UPS: ubiquitin proteasome system E1: ubiquitin activating enzyme E2: ubiquitin-conjugating enzyme E3: ubiquitin ligase DUB: deubiquitinating enzyme HECT: Homologous to E6AP C-terminus RING: Really Interesting New Gene SCF: Skp1-Cullin-Fbox PHD: plant homeodomain Ub: ubiquitin APC/C: Anaphase Promoting Complex/Cyclosome UBL: ubiquitin-like protein USP: ubiquitin-specific protease Protac: proteolysis targeting chimeric molecule References Reed SI