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While not FDA-approved drugs, both peptides require physician oversight when obtained from licensed compounding pharmacies

[iii] In vitro models, including human cells and tissues, may supplement the information regarding a drugs potential effect on humans

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In LSS, the expression of the E3 ubiquitin ligase Smurf1 is markedly elevated, which promotes fibrosis and oxidative stress in LF cells, contributing to the progression of LSS by facilitating the ubiquitination and degradation of NRF2 [112]

Gastrointestinal Therapeutics Given BPC-157's origin from gastric juice and extensive preclinical evidence for gastrointestinal protection, digestive system applications warrant clinical investigation