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In animal studies of intervertebral disc degeneration, cell-based therapeutic strategies have shown that injecting mesenchymal stem cells (MSCs) into the nucleus pulposus can allow them to survive for months and induce ECM production

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Other potential risk of the HGF/c-Met inhibition by the systemic treatment is in affecting the tissue regeneration and damage repair processes in patients, although we did not observe any side effects on our mouse models upon SU11274 administration