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This finding suggests that targeting ALDH2 in both the liver and intestine may offer a novel therapeutic approach for ALD

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TB-500 has advantages for systemic inflammation, cardiac tissue repair, and conditions requiring widespread anti-inflammatory effects

The COX and LOX pathways are the primary routes for metabolizing AA into inflammatory mediators and breaking it down into leukotrienes, prostaglandins, and some peroxides [58]

This suggests that all produced serine/glycine in NKX21 expressing cells is utilised to generate downstream metabolites