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It shows a positive association with vitamin B6 intake (13, 75, 76, 87) and responds about 10-fold to supplementation (19) and within 12 weeks to B6 depletion (51, 104) and repletion (87, 102, 110)

6 State Key Laboratory of Supramolecular Structure and Materials, Jilin University, Changchun, Peoples Republic of China *These authors contributed equally to this work Correspondence: Tianmeng Sun