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Orphanet J Rare Dis

In this context, a newly published systematic review including seven clinical trials showed that the application of vitamin B12 supplementation for metformin-treated T2DM patients will be valuable in preventing or treating vitamin B12 deficiency and neuropathy and should be considered during the T2DM management plan[32]

Your DNA Basically Decides How Much B12 You Actually Need (And Nobody Tests for This) Heres something thatll blow your mind: some peoples genes make them process B12 three times slower than others