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In this same pathway of sulfur amino acids, HCY can be metabolized producing glutathione (GSH) ( Figure 1 ) ( IL1B and CCL3 also play a central role in the pathophysiology of COVID-19 ( Figure 1 The hypothesis of this study is that, during the advanced phase of COVID-19, characterized by hyperinflammation (cytokine storm), supplemental vitamin B12 would increase the flow of the sulfur amino acid pathway, favoring the production of SAM and the antioxidant GSH

Researchers planning new work should review the most current literature before designing protocols, with attention to the gap between preclinical breadth and clinical-trial depth

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J Korean Med Sci 18: 637640