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Additionally, concerns about retinal toxicity have led to conservative dosing guidelines from the American Academy of Ophthalmology

doi:10.1111/bcp.14046 Melnikov OA, Lilenko SV, Nauta J, Ouwens MJ

Patients often dont distinguish the difference

However, two studies cited in that review indicated an 18% potency decline anywhere between week 1 and 28 days of use from when its opened

IM administration should be done with an appropriate needle to reach muscle tissue, and the site should be rotated (for example, alternate buttocks) if injections are repeated regularly to avoid soreness