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In an in vitro study on human keratoconic stromal cells (keratoconus is an eye disorder that oxidative stress may be implicated in its development), an increased gene expression of antioxidant enzymes (SOD, GPx and CAT) in riboflavin-treated cells (compared with untreated cells) was reported (Reference Cheung, McGhee and Sherwin39)

Diez V, Traikov S, Schmeisser K et al (2021) Glycolate combats massive oxidative stress by restoring redox potential in caenorhabditis elegans

The two-step binding model describes the association between the ECD and the C-terminus of the peptide ligand, as well as the interaction between the TMD and the N-terminus of the ligand