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Further flow cytometry analysis confirmed that caloric restriction modulates the PI3K/AKT/c-Myc signaling axis and reduces granulocyte-macrophage colony-stimulating factor (GM-CSF) production in Th17 cells, thereby promoting CD4 + T cell balance (127)

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Major clinical indications include glaucoma, pharmacologic induction of miosis, presbyopia, and xerostomia (dry mouth)

Dysregulated signaling at postsynaptic density: a systematic review and translational appraisal for the pathophysiology, clinics, and antipsychotics treatment of schizophrenia