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Integrating host genome-metabolome-microbiome interaction networks using systems biology approaches significantly enhances the accuracy of efficacy prediction models

4 Necroptosis in CP-induced acute kidney injury (AKI) 4.1 Fundamentals of necroptosis 4.1.1 General overview of necroptosis The term programmed cell death had been commonly used to describe caspase-dependent apoptosis until caspase-independent necrosis was identified (Weinlich et al., 2017