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10.1016/j.molcel.2013.08.003 64 JiahuiW.XiangY.YouhuanZ.XiaominM.YuanzhuG.DejianZ.et al (2025)

Additionally, the metabolism of ketone bodies increases the expression of uncoupling proteins (UCPs), which improves the efficiency of the electron transport chain during oxidative phosphorylation

MOTS-c originates from your mitochondria, which are tiny organelles found in nearly every cell in your body that are responsible for creating energy

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This is followed by nuclear-GR deacetylation by histone deacetylase 2, a required event for NF-B transcriptional repression (42, 43)