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This study describes the in vitro generation of otic neuroprogenitors that can differentiate into hair cells and sensory neurons

Unlike existing reviews that primarily discuss PROTAC biology, degrader chemistry, or delivery systems in a more general manner, this review focuses specifically on the chemistry-guided design logic of smart delivery systems for PROTACs and on how the unique structural and physicochemical features of PROTACs impose distinct delivery requirements

doi: 10.1126/science.1234089

Taking 1 mL working solution as an example, add 100 L DMSO stock solution ( 20.8 mg/mL ) to 400 L PEG300 , and mix evenly

doi: 10.1016/j.freeradbiomed.2023.03.027 18 ZhaoTYangQXiYXieZShenJLiZet al