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(24) investigated plasma mtDNA levels in RA patients and found that RA patients had a high sensitivity to mtDNA copy number compared to healthy controls, and also found that plasma mtDNA concentration was significantly correlated with the Disease Activity Score-28-Erythrocyte Sedimentation Rate (DAS28-ESR), which increased with the increase of DAS28-ESR, thus it is reasonable to believe that plasma mtDNA may be an inflammatory contributor as well as a biomarker in RA

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Based on these observations, the first vaccination cycle was followed by a second prime-boost cycle 3 weeks later with 5 10 8 PFU of rMVA-EE2-MCP and 50 g of each antigen in the rEE2-rMCP-subunit boost vaccine, also 3 weeks apart

New York, NY: Cold spring harbor laboratory press