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Overall, these findings provide new insights into redox homeostasis within eukaryotic cells, emphasizing the non-compartmentalized nature of redox regulation in membraneless organelles

10.1007/s00018-022-04385-0 12 CanterJ

227 In pathological iron overload, this DMT1 iron transport process is aggravated by increased TFR1 saturation, leading to the generation of toxic NTBI, which then causes cell damage through ferroptosis