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WJ-MSCs, which have low immunogenicity and immunomodulatory potential, have gained great interest in clinical application ( To further enhance the effectiveness of MSCs, many engineered cells have been developed that overexpress key proteins that promote proliferation and matrix production in IVD cells, including Bone morphogenetic protein 7 (BMP7) (Xu et al., 2016), Bone morphogenetic protein 2 (BMP2) (Wei et al., 2016), superoxide dismutase 2 (Sod2) and catalase (Cat) (Xiao et al., 2021)

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