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Preventive mucus physical reinforcement may, indeed, not be suitable for all individuals thickened mucus can lead to life-threatening chronic infections for patients with cystic fibrosis, for example

Despite its high rate of glucose consumption, the RBC has one of the lowest rates of ATP synthesis of any cell in the body, ~0.1 mole of ATP/kg tissue/day, reflecting the fact that anaerobic glycolysis recovers only a fraction of the energy available from complete combustion of glucose to CO 2 and H 2 O

1986 Feb;86(2):1014

There is also the circumstance when someone has another diagnosis, such as Lyme disease, but treatments have been ineffective in resolving symptoms