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The concentrations of each metabolite or ratio of metabolites values were log base 2 transformed to reduce skewness and standardized ( = 0, = 1) by subtracting the mean and dividing by the standard deviation prior to analyses

There is some indirect evidence to suggest that excess lysine in the diet may increase endogenous L-carnitine synthesis

Hence, it can be speculated, that the myocardial scarring in some PCD patients combined with an oxidative or metabolic stress can be the substrate of the increased risk of SCD in untreated patients with PCD

Il composto nell'organismo, e precisamente nel sangue, viene metabolizzato grazie a esterasi plasmatiche in carnitina, la quale viene utilizzata per trasportare gli acidi grassi nei mitocondri: gli acidi grassi vengono quindi utilizzati e ossidati