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Baseline measurements obtained from the participants determined that 64% of the participants were male, while the mean age was 58 years old, average diabetes duration was approximaely 9 years, the mean HbA1c was recorded at 8.4%, as well as an average body weight of 105.7 kg

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Research has also examined its role in upregulating matrix metalloproteinase (MMP) activity alongside their inhibitors (TIMPs), suggesting a finely balanced role in extracellular matrix remodelling rather than simple collagen deposition

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