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A deficiency in BDNF can exacerbate oxidative stress in neurons by reducing CREB activity and increasing NF-B binding activity [86,87]

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Although there was no clear evidence of the sole role of the MSCs given the differences of both protocols and even if the intensive neurorehabilitation demonstrated to have always a slight improvement compared to the ARP, an evident positive progression was observed after transplantation (T1), with all dogs from the INSCP achieving ambulation in this period (Figure 3)

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This scenario might lead to a steady state equilibrium between GRX-SG and GRX-S 2 which is fairly independent of the redox potential of the GSH/GSSG couple