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In a thirteen-week study, notable biochemical and histopathological changes were observed, but they were not of toxicological significance as PQQ levels remained within safe ranges, showing no dose-dependent toxicity (Liang et al., 2015)

Proper medical supervision is essential

Jin and Youle, 2012)

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There is evidence to suggest that presbycusis includes the accumulation of cochlear damage from various sources, and especially that of noise exposure