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Conventional drugs like metformin primarily exert their effects by improving IR, and studies have shown that they can modulate the gut microbiota, albeit with no significant impact on the levels of gut microbial metabolites (108)

Curcumin decreases amyloid-beta peptide levels by attenuating the maturation of amyloid-beta precursor protein

This finding suggests that the optimal regulator control problem formulation is both appropriate and effective, especially compared to baseline scenarios modeled by dynamical systems alone, which fail to suppress M2 macrophage density completely

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However, the antileukemic effect of ferroptosis induction will probably differ between patients because patients are heterogeneous with regard to the AML cell regulation of iron metabolism [164]