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In this capacity, it serves to shield cells from oxidative harm, thereby contributing to the preservation of cellular membrane integrity

Furthermore, a dual luciferase reporter system assay demonstrated that the luciferase activity of GGCT-3 untranslated region (UTR) (wild-type) decreased after transfection with miR-29b-3p mimics, while the luciferase activity of GGCT-3 mUTR (mut) did not show significant changes in MHCC97H and LNCaP cells (Fig

GPX4 inhibition activated ferroptosis, inducing TC cell death, rapid rise in reactive oxygen species and effectively arrested cell migration in vitro

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CDDO-Im protects from acetaminophen hepatotoxicity through induction of Nrf2-dependent genes