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Reduced PKM2 activity has been associated with enhanced cellular proliferation 152 , in agreement with earlier studies showing that posttranslational attenuation of PKM2 153 or its inhibition by oxidative stress 154 promotes tumor growth 155

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doi: 10.1038/s41586-018-0810-y 13 DouganMDranoffGDouganSK

However, considerable uncertainty remains about the (patho)physiological roles of thiol per- or polysulfidation

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