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Up to now, SIRT5/7 and HDAC1-3 of HDAC class III have been reported to function as a desuccinylase in addition to their deacetylation activity [22,23,24]

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For instance, FeSO-loaded hydrogels have demonstrated favorable therapeutic efficacy and safety in animal models of MRSA keratitis (Wang et al., 2022) and infected wounds (Wang et al., 2024), confirming the application potential of FeSO-based hydrogel formulations in treating local infections