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The PDX dataset (Neuroblastoma COJEC in vivoPDX123) and PDX-derived organoids dataset (Neuroblastoma COJEC_PDX3 organoids) from previous work 12 and from the current project for organoids (Neuroblastoma Auranofin Comb PDX1andPDX3R_org) and in vivo (NB_Aur-COJEC_PDX1_invivo) are publicly available in the R2 Genomics platform ( Analysis and visualization of heatmaps and differentially expressed genes (DEGs) were done using R2, FDR 100 for cell death

In melanocytes 4-HNE, through adduct formation, alters protein function, contributing to oxidative stress-induced cellular dysfunction, which mainly concerns on the functioning of cellular antioxidant system, acceleration of protein degradation, inhibition of melanocyte proliferation, photoaging processes, but also disruption of the intercellular interactions between melanocytes and keratinocytes 101,102,103

Benet, Leslie Z, Kroetz, Deanna L

Springer, New York, pp 2132 Lucas GNC, Leito ACC, Alencar RL, Xavier RMF, Daher EDF, Silva Junior GBD (2019) Pathophysiological aspects of nephropathy caused by non-steroidal anti-inflammatory drugs

Elesclomol Induces Copper-Dependent Ferroptosis in Colorectal Cancer Cells via Degradation of ATP7A