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doi:10.3389/fphar.2025.1551843 Park JR, Lee H, Kim SI, Yang SR

Mn also decreased the expression of N-methyl-D-aspartate (NMDA) receptors in rats, which also contributed to Mns neurotoxicity in addition to the increased concentrations of extracellular glutamate (Xu et al., 2010a)

In the context of lipid metabolism, targeting pathways such as ether lipid synthesis, fatty acid synthase (FASN), or the ACLY/ACC axis has been shown to induce mitochondrial stress and ROS accumulation, thereby enhancing apoptotic responses [144]