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AMPK activation promotes: Glucose uptake in skeletal muscle Fatty acid oxidation Mitochondrial biogenesis Suppression of energy-wasting pathways Under metabolic stress, MOTS-c can also translocate to the cell nucleus, directly regulating gene expression related to metabolism and stress response

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Loss of muscle mass, or sarcopenia, and the accompanying reduction in strength increases the risk of falls and their complications, and for many individuals the associated loss of physical, functional capacity leads to increasing difficulty in living independently

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