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Importantly: Neither peptide is FDA-approved for human use There are no large-scale human clinical trials validating safety or efficacy Quality and purity are often uncertain when purchased through underground or non-medical sources Despite this, BPC-157 and TB-500 are popular in bodybuilding, CrossFit, and athletic recovery spaces because of claims around faster healing and reduced downtime from injuries

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Mechanistic studies indicate that exercise-induced muscle contraction promotes the release of myokines (e.g., IL-6), which inhibit nuclear translocation of NF-B in hepatic Kupffer cells (Figure 2) (Milkovic et al., 2023)

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