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1989 Vordiplom in Biologie und Physiologie

Our earlier study showed that treatment of HT22 cells with erastin increased cellular lipid-ROS accumulation in a time-dependent manner 31 , and this observation was confirmed in this study (Supplementary Fig

446 This process leads to fatty acid release, causing Treg accumulation, which results in immune therapy resistance and tumor metastasis

Based on a genome comparison of the most immunogenic T cell antigens for HCMV, HHV-6, -7 and their EEHV orthologues 13,14,15,16,17,27 , a literature review and a study that aimed to identify immunogenic EEHV T cell targets 28 , the major capsid protein (MCP) and the EEHV-specific, putative regulatory protein EE2 were selected as EEHV vaccine candidate antigens