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C.GrolezG.TimmermanK.LalouxC.et al (2018)

They are not safe, and experts and physicians strongly discourage them

341 Key interactions between fragments and proteins can be elucidated through nuclear magnetic resonance (NMR), surface plasmon resonance (SPR), thermal shift assays and X-ray crystallography, enabling the identification of fragments that serve as valuable starting points for structure-guided drug development