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Studies show that drugs physically change the structure and functioning of the brain, and these documented brain changes lead to cravings (96)

The implications are substantial: A shift from symptom management to endogenous tissue restoration A credible pathway for post-injury prevention of degenerative joint disease A realistic translational bridge, given prior Phase 1 human safety data Equally important is the broader signal this sends: preservation of functionespecially in kneesis foundational to mobility, workforce readiness, injury recovery, and long-term independence

doi: 10.1177/153537020422901107

in the two-step gradient, they band at the interface (see Notes 7-9)

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