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Shikonin (SHI) is a naphthoquinone compound extracted from the root of Lithospermum erythrorhizon Siebold and Zucc, which has been widely used in Asia, and is currently believed to have less obvious side effects, and has anti-tumor (Wang et al., 2024), anti-viral (Watson et al., 2023) effects

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Data were assessed for normalisation and diaerential expression analysis was conducted using DESEQ2

These findings suggest that WD repeat-mediated protein interactions of WDR11 are key requirements for normal puberty 45,48 , corresponding to our findings in young people aged 1525 years