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Evid Based Complement Alternat Med 2021 Bellinger FP, Bellinger MT, Seale LA, Takemoto AS, Raman AV, Miki T et al (2011) Glutathione peroxidase 4 is associated with neuromelanin in substantia nigra and dystrophic axons in putamen of Parkinsons brain

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Together, these data demonstrate that oxidative stress-induced exaggerated glutathione oxidation mitigates mis-paired disulfide bond reduction causing BisAb aggregation intracellularly

In summary, the research on ATP7B and SLC31A1 adds to the growing body of evidence that highlights the importance of metal homeostasis in cancer biology

Regulatory frameworks must evolve in tandem, embracing flexible, data-driven approaches that account for the complexity and subtlety of neuroprotective interventions