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Patients should contact their GP urgently if neurological symptoms worsen, new symptoms develop, or signs of liver decompensation appear, as this may indicate inadequate treatment response or disease progression requiring specialist review

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However, vaccine performance is affected by the constant acquisition of viral mutations due to the inherent high error rate of virus RNA-dependent RNA polymerase (RdRp) and the existence of a highly variable receptor-binding motif in the spike (S) protein

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