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Based on the Bagged CART integrated algorithm and metabolomics features, diabetic retinopathy subtypes (NDR/NPDR/PDR) can be effectively classified with an accuracy of 72% and a sensitivity of 91.9%, proving that artificial intelligence models can assist in the early detection and accurate classification of diabetic complications (134)

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Indeed, glycine supplementation has been reported to slow the growth of various implanted tumors in rodents, likely owing to an antiangiogenic impact on endothelial cells.72-74 However, this effect might modestly retard wound healing.73 The antiangiogenic effect of glycine may reflect the fact that activation of endothelial NADPH oxidase, which the hyperpolarizing action of glycine may oppose, is a key mediator of the signaling pathway whereby vascular endothelial growth factor and its Flk-1 receptor promote proliferation and migration of endothelial cells.75,76 Additionally, glycine acts directly on a human hepatocyte line, via glycine receptors, to inhibit expression of vascular endothelial growth factor