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Many genetic loci and mutations have been determined that can facilitate PD (Spatola and Wider, 2014)

[DOI] [PubMed] [Google Scholar] 34.Stone JH, Khosroshahi A, Deshpande V, et al

Alcohol and Nicotine: Briefly Noted While not supplements, its worth noting two common substances: Alcohol: Alcohol can feel like it calms you initially (it increases GABA and dopamine short-term), but it also raises adrenaline and disrupts sleep, and the aldehydes from alcohol metabolism can burden detox pathways that overlap with COMTs work

J., Walensky, L

Oxidative stress and cognitive decline: the neuroprotective role of natural antioxidants