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Some commenters were not convinced that the proposed update factor is appropriate or representative of diagnostic radiopharmaceuticals, but generally did not provide an alternative update methodology

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The review confirmed that animal and human studies demonstrate adequate protein nutrition is crucial for maintenance of GSH homeostasis, and that enteral or parenteral cystine, methionine, N-acetyl-cysteine, and L-2-oxothiazolidine-4-carboxylate are effective cysteine precursors for tissue GSH synthesis