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The energy metabolism of the heart is also one of the important functions affected by muscarinic ACh receptors

These effects were confirmed in hemopexin knock-out mouse models, nominating c-MYC as a heme-regulated gene [48]

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In this respect, it is plausible that autoimmune responses, which play a role in chronic fatigue syndrome and depression [28, 119] and Long COVID [120], and pulmonary fibrosis with scarring and cardiac remodeling [71] contribute to neuropsychiatric symptoms

Patients experience severe and constant pain, along with significant functional limitations