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Enrichment analysis of CD8 + T cells demonstrated upregulation of ligand-receptor signaling, T cell activation, chemokine, cytokine, and intracellular signal transduction (Fig

Epidemiological data further support this connection: patients with inflammatory bowel disease exhibit a 28%30% increased risk of developing PD (Zhu et al., 2019), and Epstein-Barr virus infection has been linked to PD-like symptoms, highlighting the potential role of immune dysregulation in PD pathogenesis (Rajan et al., 2023

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Another study was conducted to investigate the expression of antiviral IFN-stimulated genes (ISGs) in keratinocytes transfected with HPV-2 in skin warts