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Very few human studies can be found

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This can cause symptoms such as heartburn, reflux, difficulty swallowing, and, in some cases, chest pain

furthermore, the S2-only vaccine was shown to induce nAb to both - and - coronaviruses (presumably to the fusion peptide as has been described in humans [69]), and it boosted a more broadly targeting antibody response overall than repeated homologous full-length spike vaccines [73]