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Furthermore, autophagy has been shown to promote glycolysis in hepatocellular carcinoma (HCC) cells by upregulating monocarboxylate transporter 1 (MCT1), which plays an important role in the transport of lactic acid 170

(A) The mouse optic nerve head (ONH) labels for microglia (Iba1, white) and astroglia (GFP, red) and cell bodies (blue)

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These findings also reinforce the importance of identifying macrophage subtypes that exhibit differential responses to immunotherapy, suggesting that certain subsets may resist reprogramming efforts aimed at converting M2 macrophages into a pro-inflammatory M1 phenotype (163, 164)

Traumatic brain injuryrelated emergency department visits, hospitalizations, and deathsUnited States, 2007 and 2013