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doi: 10.3389/fphys.2022.770375 17 StamouMICollingCDichtelLE

Allerdings ist die physikalisch-chemische Stabilitt dieser Peptide, beispielsweise in normaler Salzlsung, nicht zufrieden stellend

Here, we report on an Fc-engineered variant with three amino acid substitutions Q311R/M428E/N434W (REW), that enhances plasma half-life and mucosal distribution, as well as allows for needle-free delivery across respiratory epithelial barriers in human FcRn transgenic mice