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For the separate analysis of results from the investigator-initiated study and the Phase I trial, the database was locked and loaded into SAS version 9.4 (Statistical Analysis Software

4a, Supplementary Table S4)

doi: 10.1016/0092-8674(92)90611-f

The induction of diabetes and CKD using STZ and adenine, respectively, in the experimental animals resulted in significant hyperglycemia, weight loss, polyuria, impaired renal function and structure, and increased oxidative stress accompanied by a compromised antioxidant defense system and dysregulated inflammatory markers

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